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10.1080/15384101.2015.1089369 http://scihub22266oqcxt.onion/10.1080/15384101.2015.1089369 C4825607!4825607 !26397382     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26397382 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Cycle 2015 ; 14 (21 ): 3356-61 Nephropedia Template TP {{tp|p=26397382 |t=2015. Dynein prevents erroneous kinetochore-microtubule attachments in mitosis |pdf=|usr=}}{{26397382 }} gab.com Text Dynein prevents erroneous kinetochore-microtubule attachments in mitosis JO: Cell Cycle http://www.kidney.de/pget.php?&tw=1&pmid=26397382 #FOAvip Equal distribution of the genetic material during cell division relies on efficient congression of chromosomes to the metaphase plate. Prior to their alignment, the Dynein motor recruited to kinetochores transports a fraction of laterally-attached chromosomes along microtubules toward the spindle poles. By doing that, Dynein not only contributes to chromosome movements, but also prevents premature stabilization of end-on kinetochore-microtubule attachments. This is achieved by 2 parallel mechanisms: 1) Dynein-mediated poleward movement of chromosomes counteracts opposite polar-ejection forces (PEFs) on chromosome arms by the microtubule plus-end-directed motors chromokinesins. Otherwise, they could stabilize erroneous syntelic kinetochore-microtubule attachments and lead to the random ejection of chromosomes away from the spindle poles; and 2) By transporting chromosomes to the spindle poles, Dynein brings the former to the zone of highest Aurora A kinase activity, further destabilizing kinetochore-microtubule attachments. Thus, Dynein plays an important role in keeping chromosome segregation error-free by preventing premature stabilization of kinetochore-microtubule attachments near the spindle poles. Twit Text FOAVip Dynein prevents erroneous kinetochore-microtubule attachments in mitosis ????Cell Cycle http://www.kidney.de/pget.php?&tw=1&pmid=26397382 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26397382 #FOAvip English Wikipedia <ref>{{Cite pmid|26397382 }}</ref> Dynein prevents erroneous kinetochore-microtubule attachments in mitosis #MMPMID26397382 Barisic M ; Maiato H Cell Cycle 2015[]; 14 (21 ): 3356-61 PMID26397382 show ga Equal distribution of the genetic material during cell division relies on efficient congression of chromosomes to the metaphase plate. Prior to their alignment, the Dynein motor recruited to kinetochores transports a fraction of laterally-attached chromosomes along microtubules toward the spindle poles. By doing that, Dynein not only contributes to chromosome movements, but also prevents premature stabilization of end-on kinetochore-microtubule attachments. This is achieved by 2 parallel mechanisms: 1) Dynein-mediated poleward movement of chromosomes counteracts opposite polar-ejection forces (PEFs) on chromosome arms by the microtubule plus-end-directed motors chromokinesins. Otherwise, they could stabilize erroneous syntelic kinetochore-microtubule attachments and lead to the random ejection of chromosomes away from the spindle poles; and 2) By transporting chromosomes to the spindle poles, Dynein brings the former to the zone of highest Aurora A kinase activity, further destabilizing kinetochore-microtubule attachments. Thus, Dynein plays an important role in keeping chromosome segregation error-free by preventing premature stabilization of kinetochore-microtubule attachments near the spindle poles. |*Chromosome Segregation [MESH] |*Mitosis [MESH] |Animals [MESH] |Aurora Kinase A/metabolism [MESH] |Cell Polarity [MESH] |Chromosomes/*metabolism [MESH] |DNA-Binding Proteins/metabolism [MESH] |Dyneins/genetics/*metabolism [MESH] |HeLa Cells [MESH] |Humans [MESH] |Kinesins/metabolism [MESH] |Kinetochores/*metabolism [MESH] |Microtubules/*metabolism [MESH] |Nuclear Proteins/metabolism [MESH] |Protein Binding [MESH] |Signal Transduction [MESH] |Time Factors [MESH]Dynein prevents erroneous kinetochore-microtubule attachments in mitos(epmc).pdf DeepDyve Pubget Overpricing