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10.1038/cr.2015.89 http://scihub22266oqcxt.onion/10.1038/cr.2015.89 C4650629!4650629 !26206315     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26206315 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Res 2015 ; 25 (10 ): 1108-20 Nephropedia Template TP {{tp|p=26206315 |t=2015. Dynamic tubulation of mitochondria drives mitochondrial network formation |pdf=|usr=}}{{26206315 }} gab.com Text Dynamic tubulation of mitochondria drives mitochondrial network formation JO: Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=26206315 #FOAvip Mitochondria form networks. Formation of mitochondrial networks is important for maintaining mitochondrial DNA integrity and interchanging mitochondrial material, whereas disruption of the mitochondrial network affects mitochondrial functions. According to the current view, mitochondrial networks are formed by fusion of individual mitochondria. Here, we report a new mechanism for formation of mitochondrial networks through KIF5B-mediated dynamic tubulation of mitochondria. We found that KIF5B pulls thin, highly dynamic tubules out of mitochondria. Fusion of these dynamic tubules, which is mediated by mitofusins, gives rise to the mitochondrial network. We further demonstrated that dynamic tubulation and fusion is sufficient for mitochondrial network formation, by reconstituting mitochondrial networks in vitro using purified fusion-competent mitochondria, recombinant KIF5B, and polymerized microtubules. Interestingly, KIF5B only controls network formation in the peripheral zone of the cell, indicating that the mitochondrial network is divided into subzones, which may be constructed by different mechanisms. Our data not only uncover an essential mechanism for mitochondrial network formation, but also reveal that different parts of the mitochondrial network are formed by different mechanisms. Twit Text FOAVip Dynamic tubulation of mitochondria drives mitochondrial network formation ????Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=26206315 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26206315 #FOAvip English Wikipedia <ref>{{Cite pmid|26206315 }}</ref> Dynamic tubulation of mitochondria drives mitochondrial network formation #MMPMID26206315 Wang C ; Du W ; Su QP ; Zhu M ; Feng P ; Li Y ; Zhou Y ; Mi N ; Zhu Y ; Jiang D ; Zhang S ; Zhang Z ; Sun Y ; Yu L Cell Res 2015[Oct]; 25 (10 ): 1108-20 PMID26206315 show ga Mitochondria form networks. Formation of mitochondrial networks is important for maintaining mitochondrial DNA integrity and interchanging mitochondrial material, whereas disruption of the mitochondrial network affects mitochondrial functions. According to the current view, mitochondrial networks are formed by fusion of individual mitochondria. Here, we report a new mechanism for formation of mitochondrial networks through KIF5B-mediated dynamic tubulation of mitochondria. We found that KIF5B pulls thin, highly dynamic tubules out of mitochondria. Fusion of these dynamic tubules, which is mediated by mitofusins, gives rise to the mitochondrial network. We further demonstrated that dynamic tubulation and fusion is sufficient for mitochondrial network formation, by reconstituting mitochondrial networks in vitro using purified fusion-competent mitochondria, recombinant KIF5B, and polymerized microtubules. Interestingly, KIF5B only controls network formation in the peripheral zone of the cell, indicating that the mitochondrial network is divided into subzones, which may be constructed by different mechanisms. Our data not only uncover an essential mechanism for mitochondrial network formation, but also reveal that different parts of the mitochondrial network are formed by different mechanisms. |*Mitochondrial Dynamics [MESH] |Animals [MESH] |Cell Line [MESH] |GTP Phosphohydrolases [MESH] |Humans [MESH] |Kinesins/*metabolism [MESH] |Membrane Proteins/metabolism [MESH] |Mitochondria/*metabolism/*ultrastructure [MESH] |Mitochondrial Proteins/metabolism [MESH]Dynamic tubulation of mitochondria drives mitochondrial network format(epmc).pdf DeepDyve Pubget Overpricing