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Dynamic and transient cancer stem cells nurture melanoma
#MMPMID20613753
Weinberg R
; Fisher DE
; Rich J
Nat Med
2010[Jul]; 16
(7
): 758
PMID20613753
show ga
A popular?and controversial?theory is that tumors are initiated and maintained by
a fixed population of stem cell?like tumor cells. Research on human cells and
mice adds a twist to this theory, suggesting that such stem cell?like cells might
be more plastic than previously thought. Alexander Roesch et al. find that a
group of cells, which divide slowly, can sustain melanoma growth and
self-renew?hallmarks of cancer stem cells. However, the cells can switch
phenotype through epigenetic changes mediated by JARID1B, a histone modifier,
suggesting a plastic process. They found that human cells expressing JAR1D1B
could initiate and sustain melanoma growth when implanted into mice, whereas
JARD1B-negative cells could only initiate tumors. JARD1B-negative cells, however,
could switch on JARD1B to support tumor growth. Might cancer stem cells be
?moving? targets? What, then, are the therapeutic implications?
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