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2015 ; 11
(6
): 965-6
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Dual function of CALCOCO2/NDP52 during xenophagy
#MMPMID25998689
Verlhac P
; Viret C
; Faure M
Autophagy
2015[]; 11
(6
): 965-6
PMID25998689
show ga
During xenophagy, pathogens are selectively targeted by autophagy receptors to
the autophagy machinery for their subsequent degradation. In infected cells, the
autophagy receptor CALCOCO2/NDP52 targets Salmonella Typhimurium to the
phagophore membrane by concomitantly interacting with LC3C and binding to
ubiquitinated cytosolic bacteria or to LGALS8/GALECTIN 8 adsorbed on damaged
vacuoles that contain bacteria. We recently reported that in addition, CALCOCO2
is also necessary for the maturation step of Salmonella Typhimurium-containing
autophagosomes. Interestingly, the role of CALCOCO2 in maturation is independent
of its role in targeting, as these functions rely on distinct binding domains and
protein partners. Indeed, to mediate autophagosome maturation CALCOCO2 binds on
the one hand to LC3A, LC3B, or GABARAPL2, and on the other hand to MYO6/MYOSIN
VI, whereas the interaction with LC3C is dispensable. Therefore, the autophagy
receptor CALCOCO2 plays a dual function during xenophagy first by targeting
bacteria to nascent autophagosomes and then by promoting autophagosome maturation
in order to destroy bacteria.
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