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2015 ; 4
(3
): 57-60
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Drug-induced renal disorders
#MMPMID26468475
Ghane Shahrbaf F
; Assadi F
J Renal Inj Prev
2015[]; 4
(3
): 57-60
PMID26468475
show ga
Drug-induced nephrotoxicity are more common among infants and young children and
in certain clinical situations such as underlying renal dysfunction and
cardiovascular disease. Drugs can cause acute renal injury, intrarenal
obstruction, interstitial nephritis, nephrotic syndrome, and acid-base and fluid
electrolytes disorders. Certain drugs can cause alteration in intraglomerular
hemodynamics, inflammatory changes in renal tubular cells, leading to acute
kidney injury (AKI), tubulointerstitial disease and renal scarring. Drug-induced
nephrotoxicity tends to occur more frequently in patients with intravascular
volume depletion, diabetes, congestive heart failure, chronic kidney disease, and
sepsis. Therefore, early detection of drugs adverse effects is important to
prevent progression to end-stage renal disease. Preventive measures requires
knowledge of mechanisms of drug-induced nephrotoxicity, understanding patients
and drug-related risk factors coupled with therapeutic intervention by correcting
risk factors, assessing baseline renal function before initiation of therapy,
adjusting the drug dosage and avoiding use of nephrotoxic drug combinations.