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2012 ; 72
(12
): 1617-30
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Drug-induced atrial fibrillation
#MMPMID22834678
Kaakeh Y
; Overholser BR
; Lopshire JC
; Tisdale JE
Drugs
2012[Aug]; 72
(12
): 1617-30
PMID22834678
show ga
Atrial fibrillation (AF) is a common cardiac arrhythmia that is associated with
severe consequences, including symptoms, haemodynamic instability, increased
cardiovascular mortality and stroke. While other arrhythmias such as torsades de
pointes and sinus bradycardia are more typically thought of as drug induced, AF
may also be precipitated by drug therapy, although ascribing causality to
drug-associated AF is more difficult than with other drug-induced arrhythmias.
Drug-induced AF is more likely to occur in patients with risk factors and
co-morbidities that commonly co-exist with AF, such as advanced age, alcohol
consumption, family history of AF, hypertension, thyroid dysfunction, sleep
apnoea and heart disease. New-onset AF has been associated with cardiovascular
drugs such as adenosine, dobutamine and milrinone. In addition, medications such
as corticosteroids, ondansetron and antineoplastic agents such as paclitaxel,
mitoxantrone and doxorubicin have been reported to induce AF. Whether
bisphosphonate drugs are associated with new-onset AF remains controversial and
requires further study. The potential contribution of specific drug therapy
should be considered when patients present with new-onset AF.
|*Drug-Related Side Effects and Adverse Reactions
[MESH]
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