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2011 ; 12
(1
): 92-9
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Drug interactions in childhood cancer
#MMPMID20869315
Haidar C
; Jeha S
Lancet Oncol
2011[Jan]; 12
(1
): 92-9
PMID20869315
show ga
Children with cancer are increasingly benefiting from new treatment strategies
and advances in supportive care, as shown by improvements in both survival and
quality-of-life. However, the continuous emergence of new cancer drugs and
supportive-care drugs has increased the possibility of harmful drug interactions;
health-care providers need to be very cautious when combining drugs. We discuss
the most common interactions between chemotherapeutic drugs and supportive-care
drugs-such as anticonvulsants, antiemetics, uric-acid-lowering compounds, acid
suppressants, antimicrobials, and pain-management medications in paediatric
patients. We also review the interactions between chemotherapy drugs and food and
herbal supplements, and provide recommendations to avoid unwanted and potentially
fatal interactions in children with cancer. Because of the constant release of
new drugs, health-care providers need to check the most recent references before
making recommendations about drug interactions.
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