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10.1038/nrclinonc.2014.149 http://scihub22266oqcxt.onion/10.1038/nrclinonc.2014.149 C4637819!4637819 !25223555     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25223555 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25223555 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Rev+Clin+Oncol 2014 ; 11 (12 ): 732-9 Nephropedia Template TP {{tp|p=25223555 |t=2014. Drug discovery in paediatric oncology: roadblocks to progress |pdf=|usr=}}{{25223555 }} gab.com Text Drug discovery in paediatric oncology: roadblocks to progress JO: Nat Rev Clin Oncol http://www.kidney.de/pget.php?&tw=1&pmid=25223555 #FOAvip Approval of new cancer drugs for paediatric patients generally occurs after their development and approval for treating adult cancers. As most drug development occurs in the industry setting, the relatively small market of paediatric oncology does not provide the financial incentives for companies to actively pursue paediatric oncology solutions. Indeed, between 1948 and January 2003 the FDA approved 120 new cancer drugs, of which only 30 have been used in children. This slow rate of development must be addressed in a meaningful way if we are to make progress in the most pressing settings in childhood cancer. In this Viewpoint article, the key opinion leaders in the field weigh in and offer practical advice on how to address this issue. Twit Text FOAVip Drug discovery in paediatric oncology: roadblocks to progress ????Nat Rev Clin Oncol http://www.kidney.de/pget.php?&tw=1&pmid=25223555 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25223555 #FOAvip English Wikipedia <ref>{{Cite pmid|25223555 }}</ref> Drug discovery in paediatric oncology: roadblocks to progress #MMPMID25223555 Adamson PC ; Houghton PJ ; Perilongo G ; Pritchard-Jones K Nat Rev Clin Oncol 2014[Dec]; 11 (12 ): 732-9 PMID25223555 show ga Approval of new cancer drugs for paediatric patients generally occurs after their development and approval for treating adult cancers. As most drug development occurs in the industry setting, the relatively small market of paediatric oncology does not provide the financial incentives for companies to actively pursue paediatric oncology solutions. Indeed, between 1948 and January 2003 the FDA approved 120 new cancer drugs, of which only 30 have been used in children. This slow rate of development must be addressed in a meaningful way if we are to make progress in the most pressing settings in childhood cancer. In this Viewpoint article, the key opinion leaders in the field weigh in and offer practical advice on how to address this issue. |Child [MESH] |Child, Preschool [MESH] |Drug Discovery/*methods [MESH] |Humans [MESH] |Infant [MESH]Drug discovery in paediatric oncology: roadblocks to progress (epmc).pdf DeepDyve Pubget Overpricing