Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27165834
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Kidney+Int
2016 ; 89
(6
): 1211-20
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Drug discovery in focal and segmental glomerulosclerosis
#MMPMID27165834
Pullen N
; Fornoni A
Kidney Int
2016[Jun]; 89
(6
): 1211-20
PMID27165834
show ga
Despite the high medical burden experienced by patients with focal segmental
glomerulosclerosis, the etiology of the condition remains largely unknown. Focal
segmental glomerulosclerosis is highly heterogeneous in clinical and morphologic
manifestations. While this presents challenges for the development of new
treatments, research investments over the last 2 decades have yielded a surfeit
of potential avenues for therapeutic intervention. The development of many of
those ideas and concepts into new therapies, however, has been very
disappointing. Here, we describe some of the factors that have potentially
contributed to the poor translational performance from this research investment,
including the confidence we ascribe to a target, the conduct of experimental
studies, and the availability of selective reagents to test hypotheses. We will
discuss the significance of genetic and systems traits as well as other methods
for reducing bias. We will analyze the limitations of a successful drug
development. We will use specific examples hoping that these will guide a
consensus for investment and drive greater translational quality. We hope that
this substrate will serve to exemplify the tremendous opportunity for
intervention as well as facilitate greater collaborative effort between industry,
academia, and private foundations in promoting appropriate validation of these
targets. Only then will we have achieved our goal for curative therapies for this
devastating disease.
free
free
free
