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Drug development: Lessons from nature
#MMPMID28584631
Mathur S
; Hoskins C
Biomed Rep
2017[Jun]; 6
(6
): 612-614
PMID28584631
show ga
Natural products have been acknowledged for numerous years as a vital source of
active ingredients in therapeutic agents. In particular, the use of active
ingredients derived from plants for use in microbial natural products have long
been used before the dawn of modern medicine. From ancient times, the efficacy of
natural products has been associated with the chemistry, biochemistry and
synthetic activities of natural products. Thus, with scientific advancement in
modern molecular and cellular biology, analytical chemistry and pharmacology, the
unique properties of these natural products are being harnessed in order to
exploit the chemical and structural diversity and biodiversity of these types of
products in relation to their therapeutic effect. Often, new molecules of
interest in drug design units focus on the rearrangement of chemical entities or
structural isomers of naturally occurring products in order to generate new
molecules; these may be formulated into clinically useful therapies.
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