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10.3390/ijms18061316 http://scihub22266oqcxt.onion/10.3390/ijms18061316 C5486137!5486137 !28632196     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28632196 &cmd=llinks): Failed to open stream: HTTP request failed! 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Drug Hypersensitivity and Desensitizations: Mechanisms and New Approaches |pdf=|usr=}}{{28632196 }} gab.com Text Drug Hypersensitivity and Desensitizations: Mechanisms and New Approaches JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28632196 #FOAvip Drug hypersensitivity reactions (HSRs) are increasing in the 21st Century with the ever expanding availability of new therapeutic agents. Patients with cancer, chronic inflammatory diseases, cystic fibrosis, or diabetes can become allergic to their first line therapy after repeated exposures or through cross reactivity with environmental allergens. Avoidance of the offending allergenic drug may impact disease management, quality of life, and life expectancy. Precision medicine provides new tools for the understanding and management of hypersensitivity reactions (HSRs), as well as a personalized treatment approach for IgE (Immunoglobuline E) and non-IgE mediated HSRs with drug desensitization (DS). DS induces a temporary hyporesponsive state by incremental escalation of sub-optimal doses of the offending drug. In vitro models have shown evidence that IgE desensitization is an antigen-specific process which blocks calcium flux, impacts antigen/IgE/Fc?RI complex internalization and prevents the acute and late phase reactions as well as mast cell mediator release. Through a "bench to bedside" approach, in vitro desensitization models help elucidate the molecular pathways involved in DS, providing new insights to improved desensitization protocols for all patients. The aim of this review is to summarize up to date information on the drug HSRs, the IgE mediated mechanisms of desensitization, and their clinical applications. Twit Text FOAVip Drug Hypersensitivity and Desensitizations: Mechanisms and New Approaches ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28632196 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28632196 #FOAvip English Wikipedia <ref>{{Cite pmid|28632196 }}</ref> Drug Hypersensitivity and Desensitizations: Mechanisms and New Approaches #MMPMID28632196 de Las Vecillas Sánchez L ; Alenazy LA ; Garcia-Neuer M ; Castells MC Int J Mol Sci 2017[Jun]; 18 (6 ): ä PMID28632196 show ga Drug hypersensitivity reactions (HSRs) are increasing in the 21st Century with the ever expanding availability of new therapeutic agents. Patients with cancer, chronic inflammatory diseases, cystic fibrosis, or diabetes can become allergic to their first line therapy after repeated exposures or through cross reactivity with environmental allergens. Avoidance of the offending allergenic drug may impact disease management, quality of life, and life expectancy. Precision medicine provides new tools for the understanding and management of hypersensitivity reactions (HSRs), as well as a personalized treatment approach for IgE (Immunoglobuline E) and non-IgE mediated HSRs with drug desensitization (DS). DS induces a temporary hyporesponsive state by incremental escalation of sub-optimal doses of the offending drug. In vitro models have shown evidence that IgE desensitization is an antigen-specific process which blocks calcium flux, impacts antigen/IgE/Fc?RI complex internalization and prevents the acute and late phase reactions as well as mast cell mediator release. Through a "bench to bedside" approach, in vitro desensitization models help elucidate the molecular pathways involved in DS, providing new insights to improved desensitization protocols for all patients. The aim of this review is to summarize up to date information on the drug HSRs, the IgE mediated mechanisms of desensitization, and their clinical applications. |*Desensitization, Immunologic/adverse effects/methods [MESH] |Actins/metabolism [MESH] |Antigens/metabolism [MESH] |Biomarkers [MESH] |Cytokines/metabolism [MESH] |Drug Hypersensitivity/metabolism/physiopathology/prevention & control/*therapy [MESH] |Humans [MESH] |Immunoglobulin E/metabolism [MESH] |Mast Cells/drug effects/immunology [MESH] |Phenotype [MESH] |Precision Medicine [MESH]Drug Hypersensitivity and Desensitizations: Mechanisms and New Approac(epmc).pdf DeepDyve Pubget Overpricing