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http://scihub22266oqcxt.onion/ C5369029!5369029 !28356899     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28356899 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28356899 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Yale+J+Biol+Med 2017 ; 90 (1 ): 119-123 Nephropedia Template TP {{tp|p=28356899 |t=2017. Drug Development Against Metastatic Cancers |pdf=|usr=}}{{28356899 }} gab.com Text Drug Development Against Metastatic Cancers JO: Yale J Biol Med http://www.kidney.de/pget.php?&tw=1&pmid=28356899 #FOAvip While combinational diagnostic and treatment strategies over the past decades have significantly improved the overall survival of cancer patients, metastatic cancer remains a leading cause of death in developed countries. The lack of successful treatment strategies for the disease is in large part due to the complexity of the metastatic transformation, which embodies extensive cellular and extracellular alterations, enabling metastatic cancer cells to reach and colonize other organs. The mode of action for the majority of anti-cancer drugs used in clinics today is primarily tumor growth inhibition. While they are effective in destroying cancer cells, they fall short in blocking metastasis. Here we discuss the evolution of past and current anti-cancer drug development, the limits of current strategies, and possible alternative approaches for future drug development against metastatic cancers. Twit Text FOAVip Drug Development Against Metastatic Cancers ????Yale J Biol Med http://www.kidney.de/pget.php?&tw=1&pmid=28356899 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28356899 #FOAvip English Wikipedia <ref>{{Cite pmid|28356899 }}</ref> Drug Development Against Metastatic Cancers #MMPMID28356899 Wang C ; Huang S Yale J Biol Med 2017[Mar]; 90 (1 ): 119-123 PMID28356899 show ga While combinational diagnostic and treatment strategies over the past decades have significantly improved the overall survival of cancer patients, metastatic cancer remains a leading cause of death in developed countries. The lack of successful treatment strategies for the disease is in large part due to the complexity of the metastatic transformation, which embodies extensive cellular and extracellular alterations, enabling metastatic cancer cells to reach and colonize other organs. The mode of action for the majority of anti-cancer drugs used in clinics today is primarily tumor growth inhibition. While they are effective in destroying cancer cells, they fall short in blocking metastasis. Here we discuss the evolution of past and current anti-cancer drug development, the limits of current strategies, and possible alternative approaches for future drug development against metastatic cancers. |Animals [MESH] |Antineoplastic Agents/*therapeutic use [MESH] |Humans [MESH] |Neoplasm Metastasis/drug therapy [MESH]Drug Development Against Metastatic Cancers (epmc).pdf DeepDyve Pubget Overpricing