Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26389879
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26389879
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Int+J+Mol+Sci
2015 ; 16
(9
): 22094-136
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Drug Carrier for Photodynamic Cancer Therapy
#MMPMID26389879
Debele TA
; Peng S
; Tsai HC
Int J Mol Sci
2015[Sep]; 16
(9
): 22094-136
PMID26389879
show ga
Photodynamic therapy (PDT) is a non-invasive combinatorial therapeutic modality
using light, photosensitizer (PS), and oxygen used for the treatment of cancer
and other diseases. When PSs in cells are exposed to specific wavelengths of
light, they are transformed from the singlet ground state (S?) to an excited
singlet state (S?-Sn), followed by intersystem crossing to an excited triplet
state (T?). The energy transferred from T? to biological substrates and molecular
oxygen, via type I and II reactions, generates reactive oxygen species, (šO?,
H?O?, O?*, HO*), which causes cellular damage that leads to tumor cell death
through necrosis or apoptosis. The solubility, selectivity, and targeting of
photosensitizers are important factors that must be considered in PDT.
Nano-formulating PSs with organic and inorganic nanoparticles poses as potential
strategy to satisfy the requirements of an ideal PDT system. In this review, we
summarize several organic and inorganic PS carriers that have been studied to
enhance the efficacy of photodynamic therapy against cancer.
free
free
free
