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2015 ; 1849
(5
): 570-81
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Drosophila Myc: A master regulator of cellular performance
#MMPMID25010747
Grifoni D
; Bellosta P
Biochim Biophys Acta
2015[May]; 1849
(5
): 570-81
PMID25010747
show ga
The identification of the Drosophila homolog of the human MYC oncogene has
fostered a series of studies aimed to address its functions in development and
cancer biology. Due to its essential roles in many fundamental biological
processes it is hard to imagine a molecular mechanism in which MYC function is
not required. For this reason, the easily manipulated Drosophila system has
greatly helped in the dissection of the genetic and molecular pathways that
regulate and are regulated by MYC function. In this review, we focus on studies
of MYC in the fruitfly with particular emphasis on metabolism and cell
competition, highlighting the contributions of this model system in the last
decade to our understanding of MYC's complex biological nature. This article is
part of a Special Issue entitled: Myc proteins in cell biology and pathology.