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2015 ; 46
(3
): 641-7
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Dormancy models for Mycobacterium tuberculosis: A minireview
#MMPMID26413043
Alnimr AM
Braz J Microbiol
2015[Jul]; 46
(3
): 641-7
PMID26413043
show ga
Dormancy models for Mycobacterium tuberculosis play important roles in
understanding various aspects of tuberculosis pathogenesis and in the testing of
novel therapeutic regimens. By simulating the latent tuberculosis infection, in
which the bacteria exist in a non-replicative state, the models demonstrate
reduced susceptibility to antimycobacterial agents. This minireview outlines the
models available for simulating latent tuberculosis both in vitro and in several
animal species. Additionally, this minireview discusses the advantages and
disadvantages of these models for investigating the bacterial subpopulations and
susceptibilities to sterilization by various antituberculosis drugs.