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10.1590/S1517-838246320140507

http://scihub22266oqcxt.onion/10.1590/S1517-838246320140507
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suck abstract from ncbi


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pmid26413043
      Braz+J+Microbiol 2015 ; 46 (3 ): 641-7
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  • Dormancy models for Mycobacterium tuberculosis: A minireview #MMPMID26413043
  • Alnimr AM
  • Braz J Microbiol 2015[Jul]; 46 (3 ): 641-7 PMID26413043 show ga
  • Dormancy models for Mycobacterium tuberculosis play important roles in understanding various aspects of tuberculosis pathogenesis and in the testing of novel therapeutic regimens. By simulating the latent tuberculosis infection, in which the bacteria exist in a non-replicative state, the models demonstrate reduced susceptibility to antimycobacterial agents. This minireview outlines the models available for simulating latent tuberculosis both in vitro and in several animal species. Additionally, this minireview discusses the advantages and disadvantages of these models for investigating the bacterial subpopulations and susceptibilities to sterilization by various antituberculosis drugs.
  • |*Disease Models, Animal [MESH]
  • |Animals [MESH]
  • |Antitubercular Agents/*pharmacology [MESH]
  • |Drug Resistance, Bacterial [MESH]
  • |Guinea Pigs [MESH]
  • |Indicators and Reagents/pharmacology [MESH]
  • |Latent Tuberculosis/drug therapy/microbiology/*pathology [MESH]
  • |Macaca fascicularis [MESH]
  • |Mice [MESH]
  • |Mycobacterium tuberculosis/drug effects/*growth & development/metabolism [MESH]
  • |Oxazines/pharmacology [MESH]
  • |Rabbits [MESH]
  • |Tuberculosis, Pulmonary/drug therapy/microbiology/*pathology [MESH]
  • |Xanthenes/pharmacology [MESH]


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