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10.7554/eLife.34311 http://scihub22266oqcxt.onion/10.7554/eLife.34311 C5910019!5910019 !29676732     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29676732 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Elife 2018 ; 7 (ä): ä Nephropedia Template TP {{tp|p=29676732 |t=2018. Donated chemical probes for open science |pdf=|usr=}}{{29676732 }} gab.com Text Donated chemical probes for open science JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=29676732 #FOAvip Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and several of these have been made available to academia. However, probe-associated data and control compounds, such as inactive structurally related molecules and their associated data, are generally not accessible. The lack of data and guidance makes it difficult for researchers to decide which chemical tools to choose. Several pharmaceutical companies (AbbVie, Bayer, Boehringer Ingelheim, Janssen, MSD, Pfizer, and Takeda) have therefore entered into a pre-competitive collaboration to make available a large number of innovative high-quality probes, including all probe-associated data, control compounds and recommendations on use (<ext-link ext-link-type="uri" xlink:href="https://openscienceprobes.sgc-frankfurt.de">https://openscienceprobes.sgc-frankfurt.de</ext-link><ext-link ext-link-type="uri" xlink:href="https://openscienceprobes.sgc-frankfurt.de/">/</ext-link>). Here we describe the chemical tools and target-related knowledge that have been made available, and encourage others to join the project. Twit Text FOAVip Donated chemical probes for open science ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=29676732 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29676732 #FOAvip English Wikipedia <ref>{{Cite pmid|29676732 }}</ref> Donated chemical probes for open science #MMPMID29676732 Müller S ; Ackloo S ; Arrowsmith CH ; Bauser M ; Baryza JL ; Blagg J ; Böttcher J ; Bountra C ; Brown PJ ; Bunnage ME ; Carter AJ ; Damerell D ; Dötsch V ; Drewry DH ; Edwards AM ; Edwards J ; Elkins JM ; Fischer C ; Frye SV ; Gollner A ; Grimshaw CE ; IJzerman A ; Hanke T ; Hartung IV ; Hitchcock S ; Howe T ; Hughes TV ; Laufer S ; Li VM ; Liras S ; Marsden BD ; Matsui H ; Mathias J ; O'Hagan RC ; Owen DR ; Pande V ; Rauh D ; Rosenberg SH ; Roth BL ; Schneider NS ; Scholten C ; Singh Saikatendu K ; Simeonov A ; Takizawa M ; Tse C ; Thompson PR ; Treiber DK ; Viana AY ; Wells CI ; Willson TM ; Zuercher WJ ; Knapp S ; Mueller-Fahrnow A Elife 2018[Apr]; 7 (ä): ä PMID29676732 show ga Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and several of these have been made available to academia. However, probe-associated data and control compounds, such as inactive structurally related molecules and their associated data, are generally not accessible. The lack of data and guidance makes it difficult for researchers to decide which chemical tools to choose. Several pharmaceutical companies (AbbVie, Bayer, Boehringer Ingelheim, Janssen, MSD, Pfizer, and Takeda) have therefore entered into a pre-competitive collaboration to make available a large number of innovative high-quality probes, including all probe-associated data, control compounds and recommendations on use (https://openscienceprobes.sgc-frankfurt.de/). Here we describe the chemical tools and target-related knowledge that have been made available, and encourage others to join the project. |Molecular Probes/*metabolism [MESH] |Pharmacology/*methods [MESH] |Proteins/*metabolism [MESH]Donated chemical probes for open science (epmc).pdf DeepDyve Pubget Overpricing