Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26779818
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Genomics+Proteomics+Bioinformatics
2015 ; 13
(6
): 377-82
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Diversity of Gene Expression in Hepatocellular Carcinoma Cells
#MMPMID26779818
Zhang F
; Cui L
; Kuo MD
Genomics Proteomics Bioinformatics
2015[Dec]; 13
(6
): 377-82
PMID26779818
show ga
Understanding tumor diversity has been a long-lasting and challenging question
for researchers in the field of cancer heterogeneity or tumor evolution. Studies
have reported that compared to normal cells, there is a higher genetic diversity
in tumor cells, while higher genetic diversity is associated with higher
progression risks of tumor. We thus hypothesized that tumor diversity also holds
true at the gene expression level. To test this hypothesis, we used t-test to
compare the means of Simpson's diversity index for gene expression (SDIG) between
tumor and non-tumor samples. We found that the mean SDIG in tumor tissues is
significantly higher than that in the non-tumor or normal tissues (P<0.05) for
most datasets. We also combined microarrays and next-generation sequencing data
for validation. This cross-platform and cross-experimental validation greatly
increased the reliability of our results.