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10.7554/eLife.24437 http://scihub22266oqcxt.onion/10.7554/eLife.24437 C5496738!5496738 !28574339     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28574339 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Elife 2017 ; 6 (ä): ä Nephropedia Template TP {{tp|p=28574339 |t=2017. Diverse stimuli engage different neutrophil extracellular trap pathways |pdf=|usr=}}{{28574339 }} gab.com Text Diverse stimuli engage different neutrophil extracellular trap pathways JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=28574339 #FOAvip Neutrophils release neutrophil extracellular traps (NETs) which ensnare pathogens and have pathogenic functions in diverse diseases. We examined the NETosis pathways induced by five stimuli; PMA, the calcium ionophore A23187, nigericin, Candida albicans and Group B Streptococcus. We studied NET production in neutrophils from healthy donors with inhibitors of molecules crucial to PMA-induced NETs including protein kinase C, calcium, reactive oxygen species, the enzymes myeloperoxidase (MPO) and neutrophil elastase. Additionally, neutrophils from chronic granulomatous disease patients, carrying mutations in the NADPH oxidase complex or a MPO-deficient patient were examined. We show that PMA, C. albicans and GBS use a related pathway for NET induction, whereas ionophores require an alternative pathway but that NETs produced by all stimuli are proteolytically active, kill bacteria and composed mainly of chromosomal DNA. Thus, we demonstrate that NETosis occurs through several signalling mechanisms, suggesting that extrusion of NETs is important in host defence. Twit Text FOAVip Diverse stimuli engage different neutrophil extracellular trap pathways ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=28574339 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28574339 #FOAvip English Wikipedia <ref>{{Cite pmid|28574339 }}</ref> Diverse stimuli engage different neutrophil extracellular trap pathways #MMPMID28574339 Kenny EF ; Herzig A ; Krüger R ; Muth A ; Mondal S ; Thompson PR ; Brinkmann V ; Bernuth HV ; Zychlinsky A Elife 2017[Jun]; 6 (ä): ä PMID28574339 show ga Neutrophils release neutrophil extracellular traps (NETs) which ensnare pathogens and have pathogenic functions in diverse diseases. We examined the NETosis pathways induced by five stimuli; PMA, the calcium ionophore A23187, nigericin, Candida albicans and Group B Streptococcus. We studied NET production in neutrophils from healthy donors with inhibitors of molecules crucial to PMA-induced NETs including protein kinase C, calcium, reactive oxygen species, the enzymes myeloperoxidase (MPO) and neutrophil elastase. Additionally, neutrophils from chronic granulomatous disease patients, carrying mutations in the NADPH oxidase complex or a MPO-deficient patient were examined. We show that PMA, C. albicans and GBS use a related pathway for NET induction, whereas ionophores require an alternative pathway but that NETs produced by all stimuli are proteolytically active, kill bacteria and composed mainly of chromosomal DNA. Thus, we demonstrate that NETosis occurs through several signalling mechanisms, suggesting that extrusion of NETs is important in host defence. |Calcimycin/metabolism [MESH] |Candida albicans/immunology [MESH] |Extracellular Traps/*metabolism [MESH] |Granulomatous Disease, Chronic/pathology [MESH] |Healthy Volunteers [MESH] |Humans [MESH] |Metabolic Networks and Pathways [MESH] |Neutrophils/*immunology [MESH] |Nigericin/metabolism [MESH] |Streptococcus/immunology [MESH]Diverse stimuli engage different neutrophil extracellular trap pathway(epmc).pdf DeepDyve Pubget Overpricing