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10.3390/ijms18051021 http://scihub22266oqcxt.onion/10.3390/ijms18051021 C5454934!5454934 !28486410     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28486410 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28486410 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Sci 2017 ; 18 (5 ): ä Nephropedia Template TP {{tp|p=28486410 |t=2017. Diverging Concepts and Novel Perspectives in Regenerative Medicine |pdf=|usr=}}{{28486410 }} gab.com Text Diverging Concepts and Novel Perspectives in Regenerative Medicine JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28486410 #FOAvip Regenerative medicine has rapidly evolved, due to progress in cell and molecular biology allowing the isolation, characterization, expansion, and engineering of cells as therapeutic tools. Despite past limited success in the clinical translation of several promising preclinical results, this novel field is now entering a phase of renewed confidence and productivity, marked by the commercialization of the first cell therapy products. Ongoing issues in the field include the use of pluripotent vs. somatic and of allogenic vs. autologous stem cells. Moreover, the recognition that several of the observed beneficial effects of cell therapy are not due to integration of the transplanted cells, but rather to paracrine signals released by the exogenous cells, is generating new therapeutic perspectives in the field. Somatic stem cells are outperforming embryonic and induced pluripotent stem cells in clinical applications, mainly because of their more favorable safety profile. Presently, both autologous and allogeneic somatic stem cells seem to be equally safe and effective under several different conditions. Recognition that a number of therapeutic effects of transplanted cells are mediated by paracrine signals, and that such signals can be found in extracellular vesicles isolated from culture media, opens novel therapeutic perspectives in the field of regenerative medicine. Twit Text FOAVip Diverging Concepts and Novel Perspectives in Regenerative Medicine ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28486410 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28486410 #FOAvip English Wikipedia <ref>{{Cite pmid|28486410 }}</ref> Diverging Concepts and Novel Perspectives in Regenerative Medicine #MMPMID28486410 Muraca M ; Piccoli M ; Franzin C ; Tolomeo AM ; Jurga M ; Pozzobon M ; Perilongo G Int J Mol Sci 2017[May]; 18 (5 ): ä PMID28486410 show ga Regenerative medicine has rapidly evolved, due to progress in cell and molecular biology allowing the isolation, characterization, expansion, and engineering of cells as therapeutic tools. Despite past limited success in the clinical translation of several promising preclinical results, this novel field is now entering a phase of renewed confidence and productivity, marked by the commercialization of the first cell therapy products. Ongoing issues in the field include the use of pluripotent vs. somatic and of allogenic vs. autologous stem cells. Moreover, the recognition that several of the observed beneficial effects of cell therapy are not due to integration of the transplanted cells, but rather to paracrine signals released by the exogenous cells, is generating new therapeutic perspectives in the field. Somatic stem cells are outperforming embryonic and induced pluripotent stem cells in clinical applications, mainly because of their more favorable safety profile. Presently, both autologous and allogeneic somatic stem cells seem to be equally safe and effective under several different conditions. Recognition that a number of therapeutic effects of transplanted cells are mediated by paracrine signals, and that such signals can be found in extracellular vesicles isolated from culture media, opens novel therapeutic perspectives in the field of regenerative medicine. |Animals [MESH] |Extracellular Vesicles/metabolism/transplantation [MESH] |Humans [MESH] |Pluripotent Stem Cells/metabolism/transplantation [MESH] |Regenerative Medicine/*methods/trends [MESH]Diverging Concepts and Novel Perspectives in Regenerative Medicine (epmc).pdf DeepDyve Pubget Overpricing