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2017 ; 2017
(ä): 5175249
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Distinguishing the Unique Neuropathological Profile of Blast Polytrauma
#MMPMID28424745
Hubbard WB
; Greenberg S
; Norris C
; Eck J
; Lavik E
; VandeVord P
Oxid Med Cell Longev
2017[]; 2017
(ä): 5175249
PMID28424745
show ga
Traumatic brain injury sustained after blast exposure (blast-induced TBI) has
recently been documented as a growing issue for military personnel. Incidence of
injury to organs such as the lungs has decreased, though current epidemiology
still causes a great public health burden. In addition, unprotected civilians
sustain primary blast lung injury (PBLI) at alarming rates. Often,
mild-to-moderate cases of PBLI are survivable with medical intervention, which
creates a growing population of survivors of blast-induced polytrauma (BPT) with
symptoms from blast-induced mild TBI (mTBI). Currently, there is a lack of
preclinical models simulating BPT, which is crucial to identifying unique injury
mechanisms of BPT and its management. To meet this need, our group characterized
a rodent model of BPT and compared results to a blast-induced mTBI model. Open
field (OF) performance trials were performed on rodents at 7 days after injury.
Immunohistochemistry was performed to evaluate cellular outcome at day seven
following BPT. Levels of reactive astrocytes (GFAP), apoptosis (cleaved caspase-3
expression), and vascular damage (SMI-71) were significantly elevated in BPT
compared to blast-induced mTBI. Downstream markers of hypoxia (HIF-1? and VEGF)
were higher only after BPT. This study highlights the need for unique
therapeutics and prehospital management when handling BPT.
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