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2018 ; 13
(3
): e0193975
Nephropedia Template TP
PLoS One
2018[]; 13
(3
): e0193975
PMID29529095
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Motivated by in vitro time-lapse images of ovarian cancer spheroids inducing
mesothelial cell clearance, the traditional agent-based model of cell migration,
based on simple volume exclusion, was extended to include the possibility that a
cell seeking to move into an occupied location may push the resident cell, and
any cells neighbouring it, out of the way to occupy that location. In traditional
discrete models of motile cells with volume exclusion such a move would be
aborted. We introduce a new shoving mechanism which allows cells to choose the
direction to shove cells that expends the least amount of shoving effort (to
account for the likely resistance of cells to being pushed). We call this
motility rule 'smart shoving'. We examine whether agent-based simulations of
different shoving mechanisms can be distinguished on the basis of single
realisations and averages over many realisations. We emphasise the difficulty in
distinguishing cell mechanisms from cellular automata simulations based on
snap-shots of cell distributions, site-occupancy averages and the evolution of
the number of cells of each species averaged over many realisations. This
difficulty suggests the need for higher resolution cell tracking.
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