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10.1016/j.neuroimage.2015.03.015 http://scihub22266oqcxt.onion/10.1016/j.neuroimage.2015.03.015 C4408248!4408248 !25776211     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25776211 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Neuroimage 2015 ; 112 (ä): 197-207 Nephropedia Template TP {{tp|p=25776211 |t=2015. Distinct neural representations of placebo and nocebo effects |pdf=|usr=}}{{25776211 }} gab.com Text Distinct neural representations of placebo and nocebo effects JO: Neuroimage http://www.kidney.de/pget.php?&tw=1&pmid=25776211 #FOAvip Expectations shape the way we experience the world. In this study, we used fMRI to investigate how positive and negative expectation can change pain experiences in the same cohort of subjects. We first manipulated subjects' treatment expectation of the effectiveness of three inert creams, with one cream labeled "Lidocaine" (positive expectancy), one labeled "Capsaicin" (negative expectancy) and one labeled "Neutral" by surreptitiously decreasing, increasing, or not changing respectively, the intensity of the noxious stimuli administered following cream application. We then used fMRI to investigate the signal changes associated with administration of identical pain stimuli before and after the treatment and control creams. Twenty-four healthy adults completed the study. Results showed that expectancy significantly modulated subjective pain ratings. After controlling for changes in the neutral condition, the subjective pain rating changes evoked by positive and negative expectancies were significantly associated. fMRI results showed that the expectation of an increase in pain induced significant fMRI signal changes in the insula, orbitofrontal cortex, and periaqueductal gray, whereas the expectation of pain relief evoked significant fMRI signal changes in the striatum. No brain regions were identified as common to both "Capsaicin" and "Lidocaine" conditioning. There was also no significant association between the brain response to identical noxious stimuli in the pain matrix evoked by positive and negative expectancies. Our findings suggest that positive and negative expectancies engage different brain networks to modulate our pain experiences, but, overall, these distinct patterns of neural activation result in a correlated placebo and nocebo behavioral response. Twit Text FOAVip Distinct neural representations of placebo and nocebo effects ????Neuroimage http://www.kidney.de/pget.php?&tw=1&pmid=25776211 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25776211 #FOAvip English Wikipedia <ref>{{Cite pmid|25776211 }}</ref> Distinct neural representations of placebo and nocebo effects #MMPMID25776211 Freeman S ; Yu R ; Egorova N ; Chen X ; Kirsch I ; Claggett B ; Kaptchuk TJ ; Gollub RL ; Kong J Neuroimage 2015[May]; 112 (ä): 197-207 PMID25776211 show ga Expectations shape the way we experience the world. In this study, we used fMRI to investigate how positive and negative expectation can change pain experiences in the same cohort of subjects. We first manipulated subjects' treatment expectation of the effectiveness of three inert creams, with one cream labeled "Lidocaine" (positive expectancy), one labeled "Capsaicin" (negative expectancy) and one labeled "Neutral" by surreptitiously decreasing, increasing, or not changing respectively, the intensity of the noxious stimuli administered following cream application. We then used fMRI to investigate the signal changes associated with administration of identical pain stimuli before and after the treatment and control creams. Twenty-four healthy adults completed the study. Results showed that expectancy significantly modulated subjective pain ratings. After controlling for changes in the neutral condition, the subjective pain rating changes evoked by positive and negative expectancies were significantly associated. fMRI results showed that the expectation of an increase in pain induced significant fMRI signal changes in the insula, orbitofrontal cortex, and periaqueductal gray, whereas the expectation of pain relief evoked significant fMRI signal changes in the striatum. No brain regions were identified as common to both "Capsaicin" and "Lidocaine" conditioning. There was also no significant association between the brain response to identical noxious stimuli in the pain matrix evoked by positive and negative expectancies. Our findings suggest that positive and negative expectancies engage different brain networks to modulate our pain experiences, but, overall, these distinct patterns of neural activation result in a correlated placebo and nocebo behavioral response. |*Nocebo Effect [MESH] |*Placebo Effect [MESH] |Adult [MESH] |Anesthetics, Local/pharmacology [MESH] |Capsaicin/pharmacology [MESH] |Cerebral Cortex/physiology [MESH] |Female [MESH] |Hot Temperature [MESH] |Humans [MESH] |Lidocaine/pharmacology [MESH] |Magnetic Resonance Imaging [MESH] |Male [MESH] |Middle Aged [MESH] |Nervous System/*drug effects [MESH] |Pain Perception/drug effects [MESH] |Pain/psychology [MESH] |Periaqueductal Gray/physiology [MESH] |Reward [MESH] |Set, Psychology [MESH]Distinct neural representations of placebo and nocebo effects (epmc).pdf DeepDyve Pubget Overpricing