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2014 ; 10
(4
): 642-51
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Dissection of autophagy in human platelets
#MMPMID24458007
Feng W
; Chang C
; Luo D
; Su H
; Yu S
; Hua W
; Chen Z
; Hu H
; Liu W
Autophagy
2014[Apr]; 10
(4
): 642-51
PMID24458007
show ga
Continuous turnover of intracellular components by autophagy is necessary to
preserve cellular homeostasis in all tissues. Despite recent advances in
identifying autophagy-related genes and understanding the functions of autophagy
in developmental and pathological conditions, so far, the role of autophagy in
platelet, a specific anucleate cell type, is poorly understood. In this study, we
showed that human platelets express the autophagy-related proteins ATG5, ATG7,
and LC3. The same as in nucleated mammalian cells, autophagy was stimulated by
cell starvation or the MTOR inhibitor rapamycin in a phosphatidylinositol
3-kinase (PtdIns3K)-dependent manner. Disruption of autophagic flux led to
impairment of platelet aggregation and adhesion. Furthermore, Becn1 heterozygous
knockout mice displayed a prolonged bleeding time and reduced platelet
aggregation. These results suggest a potential role of autophagy in the
regulation of platelet function, and imply that gene transcription may not be an
essential prerequisite for adaptive autophagy.
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