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2014 ; 9
(4
): 505-12
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Disrupted neural processing of emotional faces in psychopathy
#MMPMID23386739
Contreras-Rodríguez O
; Pujol J
; Batalla I
; Harrison BJ
; Bosque J
; Ibern-Regàs I
; Hernández-Ribas R
; Soriano-Mas C
; Deus J
; López-Solà M
; Pifarré J
; Menchón JM
; Cardoner N
Soc Cogn Affect Neurosci
2014[Apr]; 9
(4
): 505-12
PMID23386739
show ga
Psychopaths show a reduced ability to recognize emotion facial expressions, which
may disturb the interpersonal relationship development and successful social
adaptation. Behavioral hypotheses point toward an association between emotion
recognition deficits in psychopathy and amygdala dysfunction. Our prediction was
that amygdala dysfunction would combine deficient activation with disturbances in
functional connectivity with cortical regions of the face-processing network.
Twenty-two psychopaths and 22 control subjects were assessed and functional
magnetic resonance maps were generated to identify both brain activation and
task-induced functional connectivity using psychophysiological interaction
analysis during an emotional face-matching task. Results showed significant
amygdala activation in control subjects only, but differences between study
groups did not reach statistical significance. In contrast, psychopaths showed
significantly increased activation in visual and prefrontal areas, with this
latest activation being associated with psychopaths' affective-interpersonal
disturbances. Psychophysiological interaction analyses revealed a reciprocal
reduction in functional connectivity between the left amygdala and visual and
prefrontal cortices. Our results suggest that emotional stimulation may evoke a
relevant cortical response in psychopaths, but a disruption in the processing of
emotional faces exists involving the reciprocal functional interaction between
the amygdala and neocortex, consistent with the notion of a failure to integrate
emotion into cognition in psychopathic individuals.
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