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2015 ; 35
(41
): 13889-95
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Disrupted Sleep: From Molecules to Cognition
#MMPMID26468189
Van Someren EJ
; Cirelli C
; Dijk DJ
; Van Cauter E
; Schwartz S
; Chee MW
J Neurosci
2015[Oct]; 35
(41
): 13889-95
PMID26468189
show ga
Although the functions of sleep remain to be fully elucidated, it is clear that
there are far-reaching effects of its disruption, whether by curtailment for a
single night, by a few hours each night over a long period, or by disruption in
sleep continuity. Epidemiological and experimental studies of these different
forms of sleep disruption show deranged physiology from subcellular levels to
complex affective behavior. In keeping with the multifaceted influence of sleep
on health and well-being, we illustrate how the duration of sleep, its timing,
and continuity can affect cellular ultrastructure, gene expression, metabolic and
hormone regulation, mood, and vigilance. Recent brain imaging studies provide
some clues on mechanisms underlying the most common cause of disrupted sleep
(insomnia). These insights should ultimately result in adequate interventions to
prevent and treat sleep disruption because of their high relevance to our most
prevalent health problems. SIGNIFICANCE STATEMENT: Disruption of the duration,
timing, and continuity of sleep affects cellular ultrastructure, gene expression,
appetite regulation, hormone production, vigilance, and reward functions.
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