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2013 ; 11
(1
): 27-32
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Disorders of sexual differentiation: II Diagnosis and treatment
#MMPMID26579241
El-Sherbiny M
Arab J Urol
2013[Mar]; 11
(1
): 27-32
PMID26579241
show ga
OBJECTIVES: To provide a review and summary of recent advances in the diagnosis
and management of disorder(s) of sexual differentiation (DSD), an area that has
developed over recent years with implications for the management of children with
DSD; and to assess the refinements in the surgical techniques used for genital
reconstruction. METHODS: Recent publications (in the previous 10 years) were
identified using PubMed, as were relevant previous studies, using following
keywords; 'diagnosis and management', 'ambiguous genitalia', 'intersex',
'disorders of sexual differentiation', 'genitogram', 'endocrine assessment',
'gender assignment', 'genitoplasty', and 'urogenital sinus'. The findings were
reviewed. RESULTS: Arbitrary criteria have been developed to select patients
likely to have DSD. Unnecessary tests, especially those that require anaesthesia
or are associated with radiation exposure, should be limited to situations where
a specific question needs to be answered. Laparoscopy is an important diagnostic
tool in selected patients. The routine use of multidisciplinary diagnostic and
expert surgical teams has become standard. Full disclosure of different
therapeutic approaches and their timing is recommended. CONCLUSIONS: Diagnostic
tests should be tailored according to the available information. Parents and/or
patients should be made aware of the paucity of well-designed studies, as these
conditions are rare. Unnecessary irreversible surgery should be postponed until a
multidisciplinary experienced team, with the parents' and or patients' approval,
can make a well-judged decision.