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2015 ; 21
(4
): 212-22
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English Wikipedia
Disease implications of the Hippo/YAP pathway
#MMPMID25702974
Plouffe SW
; Hong AW
; Guan KL
Trends Mol Med
2015[Apr]; 21
(4
): 212-22
PMID25702974
show ga
The Hippo signaling pathway is important for controlling organ size and tissue
homeostasis. Originally identified in Drosophila melanogaster, the core
components of the Hippo pathway are highly conserved in mammals. The Hippo
pathway can be modulated by a wide range of stimuli, including G protein-coupled
receptor (GPCR) signaling, changes in the actin cytoskeleton, cell-cell contact,
and cell polarity. When activated, the Hippo pathway functions as a tumor
suppressor to limit cell growth. However, dysregulation by genetic inactivation
of core pathway components or amplification or gene fusion of its downstream
effectors results in increased cell proliferation and decreased apoptosis and
differentiation. Unsurprisingly, this can lead to tissue overgrowth,
tumorigenesis, and many other diseases.
|*Signal Transduction
[MESH]
|Animals
[MESH]
|Apoptosis
[MESH]
|Carcinogenesis
[MESH]
|Cell Proliferation
[MESH]
|Drosophila Proteins/genetics/*metabolism
[MESH]
|Drosophila melanogaster
[MESH]
|Gene Expression Regulation, Developmental
[MESH]
|Gene Expression Regulation, Neoplastic
[MESH]
|Hippo Signaling Pathway
[MESH]
|Homeostasis
[MESH]
|Humans
[MESH]
|Intracellular Signaling Peptides and Proteins/genetics/*metabolism
[MESH]
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