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2016 ; 6
(10
): ä Nephropedia Template TP
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Disease implication of hyper-Hippo signalling
#MMPMID27805903
Wang SP
; Wang LH
Open Biol
2016[Oct]; 6
(10
): ä PMID27805903
show ga
The Hippo signalling pathway regulates cellular proliferation, apoptosis and
differentiation, thus exerting profound effects on cellular homeostasis.
Inhibition of Hippo signalling has been frequently implicated in human cancers,
indicating a well-known tumour suppressor function of the Hippo pathway. However,
it is less certain whether and how hyperactivation of the Hippo pathway affects
biological outcome in living cells. This review describes current knowledge of
the regulatory mechanisms of the Hippo pathway, mainly focusing on
hyperactivation of the Hippo signalling nexus. The disease implications of
hyperactivated Hippo signalling have also been discussed, including
arrhythmogenic cardiomyopathy, Sveinsson's chorioretinal atrophy, Alzheimer's
disease, amyotrophic lateral sclerosis and diabetes. By highlighting the
significance of disease-relevant Hippo signalling activation, this review can
offer exciting prospects to address the onset and potential reversal of
Hippo-related disorders.
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