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10.3389/fgene.2017.00040 http://scihub22266oqcxt.onion/10.3389/fgene.2017.00040 C5385377!5385377 !28443132     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28443132 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Front+Genet 2017 ; 8 (ä): 40 Nephropedia Template TP {{tp|p=28443132 |t=2017. Disease Resistance and the Definition of Genetic Enhancement |pdf=|usr=}}{{28443132 }} gab.com Text Disease Resistance and the Definition of Genetic Enhancement JO: Front Genet http://www.kidney.de/pget.php?&tw=1&pmid=28443132 #FOAvip Recent gene editing experiments carried out in human embryos have raised the question of whether interventions like the introduction of a CCR5-?32 deletion, which could provide heritable resistance to HIV infection, ought to be considered enhancements. Many authors have used the term "enhancement" in different ways, some based on patients' biomedical outcomes and others on their social context. These classifications are often considered overly imprecise. Nevertheless, the concept of "enhancement" could affect the ways in which these applications are regulated in different jurisdictions, the availability of coverage by insurers or public health care, and the force of public opinion in shaping future policy on gene editing. In order to ethically situate resistance to communicable disease with reference to other techniques, this article provides an overview of its similarities and differences with disease gene therapy in embryos, gene therapy in consenting adults, and vaccination. In discussing key ethical features of CCR5-?32 deletion (including its frequency in various populations, biological mechanism, benefits for individuals, and use in previous clinical trials) we offer some potential guideposts for the continuing discussion on how to classify "enhancements" in the age of CRISPR gene editing. Twit Text FOAVip Disease Resistance and the Definition of Genetic Enhancement ????Front Genet http://www.kidney.de/pget.php?&tw=1&pmid=28443132 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28443132 #FOAvip English Wikipedia <ref>{{Cite pmid|28443132 }}</ref> Disease Resistance and the Definition of Genetic Enhancement #MMPMID28443132 So D ; Kleiderman E ; Touré SB ; Joly Y Front Genet 2017[]; 8 (ä): 40 PMID28443132 show ga Recent gene editing experiments carried out in human embryos have raised the question of whether interventions like the introduction of a CCR5-?32 deletion, which could provide heritable resistance to HIV infection, ought to be considered enhancements. Many authors have used the term "enhancement" in different ways, some based on patients' biomedical outcomes and others on their social context. These classifications are often considered overly imprecise. Nevertheless, the concept of "enhancement" could affect the ways in which these applications are regulated in different jurisdictions, the availability of coverage by insurers or public health care, and the force of public opinion in shaping future policy on gene editing. In order to ethically situate resistance to communicable disease with reference to other techniques, this article provides an overview of its similarities and differences with disease gene therapy in embryos, gene therapy in consenting adults, and vaccination. In discussing key ethical features of CCR5-?32 deletion (including its frequency in various populations, biological mechanism, benefits for individuals, and use in previous clinical trials) we offer some potential guideposts for the continuing discussion on how to classify "enhancements" in the age of CRISPR gene editing. äDisease Resistance and the Definition of Genetic Enhancement (epmc).pdf DeepDyve Pubget Overpricing