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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Interferon+Cytokine+Res
2017 ; 37
(5
): 184-197
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Discrimination of Self and Non-Self Ribonucleic Acids
#MMPMID28475460
Gebhardt A
; Laudenbach BT
; Pichlmair A
J Interferon Cytokine Res
2017[May]; 37
(5
): 184-197
PMID28475460
show ga
Most virus infections are controlled through the innate and adaptive immune
system. A surprisingly limited number of so-called pattern recognition receptors
(PRRs) have the ability to sense a large variety of virus infections. The reason
for the broad activity of PRRs lies in the ability to recognize viral nucleic
acids. These nucleic acids lack signatures that are present in cytoplasmic
cellular nucleic acids and thereby marking them as pathogen-derived. Accumulating
evidence suggests that these signatures, which are predominantly sensed by a
class of PRRs called retinoic acid-inducible gene I (RIG-I)-like receptors and
other proteins, are not unique to viruses but rather resemble immature forms of
cellular ribonucleic acids generated by cellular polymerases. RIG-I-like
receptors, and other cellular antiviral proteins, may therefore have mainly
evolved to sense nonprocessed nucleic acids typically generated by primitive
organisms and pathogens. This capability has not only implications on induction
of antiviral immunity but also on the function of cellular proteins to handle
self-derived RNA with stimulatory potential.
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