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2016 ; 6
(ä): 65-80
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Discrimination Between Normal and Cancerous Cells Using AFM
#MMPMID27014560
Lekka M
Bionanoscience
2016[]; 6
(ä): 65-80
PMID27014560
show ga
Currently, biomechanics of living cells is in the focus of interest due to
noticeable capability of such techniques like atomic force microscopy (AFM) to
probe cellular properties at the single cell level directly on living cells. The
research carried out, so far, delivered data showing, on the one hand, the use of
cellular mechanics as a biomarker of various pathological changes, which, on the
other hand, reveal relative nature of biomechanics. In the AFM, the elastic
properties of living cells are delivered from indentation experiments and
described quantitatively by Young's modulus defined here as a measure of cellular
deformability. Here, the AFM studies directly comparing the mechanical properties
of normal and cancerous cells are summarized and presented together with a few
important issues related to the relativeness of Young's modulus.