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10.1172/jci.insight.91327 http://scihub22266oqcxt.onion/10.1172/jci.insight.91327 C5333972!5333972 !28289720     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28289720 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28289720 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       JCI+Insight 2017 ; 2 (5 ): e91327 Nephropedia Template TP {{tp|p=28289720 |t=2017. Discerning functional hierarchies of microRNAs in pulmonary hypertension |pdf=|usr=}}{{28289720 }} gab.com Text Discerning functional hierarchies of microRNAs in pulmonary hypertension JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=28289720 #FOAvip Pulmonary hypertension (PH) is a multifaceted vascular disease where development and severity are determined by both genetic and environmental factors. Over the past decade, there has been an acceleration of the discovery of molecular effectors that mediate PH pathogenesis, including large numbers of microRNA molecules that are expressed in pulmonary vascular cell types and exert system-wide regulatory functions in all aspects of vascular health and disease. Due to the inherent pleiotropy, overlap, and redundancy of these molecules, it has been challenging to define their integrated effects on overall disease manifestation. In this review, we summarize our current understanding of the roles of microRNAs in PH with an emphasis on potential methods to discern the hierarchical motifs governing their multifunctional and interconnected activities. Deciphering this higher order of regulatory structure will be crucial for overcoming the challenges of developing these molecules as biomarkers or therapeutic targets, in isolation or combination. Twit Text FOAVip Discerning functional hierarchies of microRNAs in pulmonary hypertension ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=28289720 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28289720 #FOAvip English Wikipedia <ref>{{Cite pmid|28289720 }}</ref> Discerning functional hierarchies of microRNAs in pulmonary hypertension #MMPMID28289720 Negi V ; Chan SY JCI Insight 2017[Mar]; 2 (5 ): e91327 PMID28289720 show ga Pulmonary hypertension (PH) is a multifaceted vascular disease where development and severity are determined by both genetic and environmental factors. Over the past decade, there has been an acceleration of the discovery of molecular effectors that mediate PH pathogenesis, including large numbers of microRNA molecules that are expressed in pulmonary vascular cell types and exert system-wide regulatory functions in all aspects of vascular health and disease. Due to the inherent pleiotropy, overlap, and redundancy of these molecules, it has been challenging to define their integrated effects on overall disease manifestation. In this review, we summarize our current understanding of the roles of microRNAs in PH with an emphasis on potential methods to discern the hierarchical motifs governing their multifunctional and interconnected activities. Deciphering this higher order of regulatory structure will be crucial for overcoming the challenges of developing these molecules as biomarkers or therapeutic targets, in isolation or combination. |Animals [MESH] |Humans [MESH] |Hypertension, Pulmonary/*genetics [MESH]Discerning functional hierarchies of microRNAs in pulmonary hypertensi(epmc).pdf DeepDyve Pubget Overpricing