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2018 ; 18
(1
): 50
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Disbiome database: linking the microbiome to disease
#MMPMID29866037
Janssens Y
; Nielandt J
; Bronselaer A
; Debunne N
; Verbeke F
; Wynendaele E
; Van Immerseel F
; Vandewynckel YP
; De Tré G
; De Spiegeleer B
BMC Microbiol
2018[Jun]; 18
(1
): 50
PMID29866037
show ga
BACKGROUND: Recent research has provided fascinating indications and evidence
that the host health is linked to its microbial inhabitants. Due to the
development of high-throughput sequencing technologies, more and more data
covering microbial composition changes in different disease types are emerging.
However, this information is dispersed over a wide variety of medical and
biomedical disciplines. DESCRIPTION: Disbiome is a database which collects and
presents published microbiota-disease information in a standardized way. The
diseases are classified using the MedDRA classification system and the
micro-organisms are linked to their NCBI and SILVA taxonomy. Finally, each study
included in the Disbiome database is assessed for its reporting quality using a
standardized questionnaire. CONCLUSIONS: Disbiome is the first database giving a
clear, concise and up-to-date overview of microbial composition differences in
diseases, together with the relevant information of the studies published. The
strength of this database lies within the combination of the presence of
references to other databases, which enables both specific and diverse search
strategies within the Disbiome database, and the human annotation which ensures a
simple and structured presentation of the available data.
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