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2014 ; 9
(5
): 1075-85
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Directing the immune system with chemical compounds
#MMPMID24690004
Mancini RJ
; Stutts L
; Ryu KA
; Tom JK
; Esser-Kahn AP
ACS Chem Biol
2014[May]; 9
(5
): 1075-85
PMID24690004
show ga
Agonists of immune cell receptors direct innate and adaptive immunity. These
agonists range in size and complexity from small molecules to large
macromolecules. Here, agonists of a class of immune cell receptors known as the
Toll-like receptors (TLRs) are highlighted focusing on the distinctive molecular
moieties that pertain to receptor binding and activation. How the structure and
combined chemical signals translate into a variety of immune responses remain
major questions in the field. In this structure-focused review, we outline
potential areas where the tools of chemical biology could help decipher the
emerging molecular codes that direct immune stimulation.