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10.1021/cb500079s

http://scihub22266oqcxt.onion/10.1021/cb500079s
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C5674983!5674983 !24690004
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suck abstract from ncbi


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pmid24690004
      ACS+Chem+Biol 2014 ; 9 (5 ): 1075-85
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  • Directing the immune system with chemical compounds #MMPMID24690004
  • Mancini RJ ; Stutts L ; Ryu KA ; Tom JK ; Esser-Kahn AP
  • ACS Chem Biol 2014[May]; 9 (5 ): 1075-85 PMID24690004 show ga
  • Agonists of immune cell receptors direct innate and adaptive immunity. These agonists range in size and complexity from small molecules to large macromolecules. Here, agonists of a class of immune cell receptors known as the Toll-like receptors (TLRs) are highlighted focusing on the distinctive molecular moieties that pertain to receptor binding and activation. How the structure and combined chemical signals translate into a variety of immune responses remain major questions in the field. In this structure-focused review, we outline potential areas where the tools of chemical biology could help decipher the emerging molecular codes that direct immune stimulation.
  • |Adaptive Immunity/drug effects [MESH]
  • |Adjuvants, Immunologic/*chemistry/*pharmacology [MESH]
  • |Animals [MESH]
  • |Humans [MESH]
  • |Immune System/drug effects/immunology [MESH]
  • |Immunity, Innate/drug effects [MESH]
  • |Models, Molecular [MESH]
  • |Signal Transduction/drug effects [MESH]


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