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10.1074/jbc.R115.653204 http://scihub22266oqcxt.onion/10.1074/jbc.R115.653204 C4505450!4505450!25947377     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25947377&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25947377.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Biol+Chem 2015 ; 290 (25): 15371-9 Nephropedia Template TP {{tp|p=25947377|t=2015. Dihydroceramides: From Bit Players to Lead Actors* |pdf=|usr=}}{{25947377}} gab.com Text Dihydroceramides: From Bit Players to Lead Actors* JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25947377 #FOAvip Sphingolipid synthesis involves a highly conserved biosynthetic pathway that produces fundamental precursors of complex sphingolipids. The final reaction involves the insertion of a double bond into dihydroceramides to generate the more abundant ceramides, which are converted to sphingomyelins and glucosylceramides/gangliosides by the addition of polar head groups. Although ceramides have long been known to mediate cellular stress responses, the dihydroceramides that are transiently produced during de novo sphingolipid synthesis were deemed inert. Evidence published in the last few years suggests that these dihydroceramides accumulate to a far greater extent in tissues than previously thought. Moreover, they have biological functions that are distinct and non-overlapping with those of the more prevalent ceramides. Roles are being uncovered in autophagy, hypoxia, and cellular proliferation, and the lipids are now implicated in the etiology, treatment, and/or diagnosis of diabetes, cancer, ischemia/reperfusion injury, and neurodegenerative diseases. This minireview summarizes recent findings on this emerging class of bioactive lipids. Twit Text FOAVip Dihydroceramides: From Bit Players to Lead Actors* ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25947377 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25947377 #FOAvip English Wikipedia <ref>{{Cite pmid|25947377}}</ref> Dihydroceramides: From Bit Players to Lead Actors* #MMPMID25947377 Siddique MM; Li Y; Chaurasia B; Kaddai VA; Summers SA J Biol Chem 2015[Jun]; 290 (25): 15371-9 PMID25947377show ga Sphingolipid synthesis involves a highly conserved biosynthetic pathway that produces fundamental precursors of complex sphingolipids. The final reaction involves the insertion of a double bond into dihydroceramides to generate the more abundant ceramides, which are converted to sphingomyelins and glucosylceramides/gangliosides by the addition of polar head groups. Although ceramides have long been known to mediate cellular stress responses, the dihydroceramides that are transiently produced during de novo sphingolipid synthesis were deemed inert. Evidence published in the last few years suggests that these dihydroceramides accumulate to a far greater extent in tissues than previously thought. Moreover, they have biological functions that are distinct and non-overlapping with those of the more prevalent ceramides. Roles are being uncovered in autophagy, hypoxia, and cellular proliferation, and the lipids are now implicated in the etiology, treatment, and/or diagnosis of diabetes, cancer, ischemia/reperfusion injury, and neurodegenerative diseases. This minireview summarizes recent findings on this emerging class of bioactive lipids. äDihydroceramides: From Bit Players to Lead Actors* (epmc).pdf DeepDyve Pubget Overpricing