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2020 ; 7
(5
): 119-128
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Digesting the crisis: autophagy and coronaviruses
#MMPMID32391393
Carmona-Gutierrez D
; Bauer MA
; Zimmermann A
; Kainz K
; Hofer SJ
; Kroemer G
; Madeo F
Microb Cell
2020[May]; 7
(5
): 119-128
PMID32391393
show ga
Autophagy is a catabolic pathway with multifaceted roles in cellular homeostasis.
This process is also involved in the antiviral response at multiple levels,
including the direct elimination of intruding viruses (virophagy), the
presentation of viral antigens, the fitness of immune cells, and the inhibition
of excessive inflammatory reactions. In line with its central role in immunity,
viruses have evolved mechanisms to interfere with or to evade the autophagic
process, and in some cases, even to harness autophagy or constituents of the
autophagic machinery for their replication. Given the devastating consequences of
the current COVID-19 pandemic, the question arises whether manipulating autophagy
might be an expedient approach to fight the novel coronavirus SARS-CoV-2. In this
piece, we provide a short overview of the evidence linking autophagy to
coronaviruses and discuss whether such links may provide actionable targets for
therapeutic interventions.
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