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2015 ; 7
(10
): 319-28
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Diffusion-weighted imaging of pancreatic cancer
#MMPMID26516428
De Robertis R
; Tinazzi Martini P
; Demozzi E
; Dal Corso F
; Bassi C
; Pederzoli P
; D'Onofrio M
World J Radiol
2015[Oct]; 7
(10
): 319-28
PMID26516428
show ga
Magnetic resonance imaging (MRI) is a reliable and accurate imaging method for
the evaluation of patients with pancreatic ductal adenocarcinoma (PDAC).
Diffusion-weighted imaging (DWI) is a relatively recent technological improvement
that expanded MRI capabilities, having brought functional aspects into
conventional morphologic MRI evaluation. DWI can depict the random diffusion of
water molecules within tissues (the so-called Brownian motions). Modifications of
water diffusion induced by different factors acting on the extracellular and
intracellular spaces, as increased cell density, edema, fibrosis, or altered
functionality of cell membranes, can be detected using this MR sequence. The
intravoxel incoherent motion (IVIM) model is an advanced DWI technique that
consent a separate quantitative evaluation of all the microscopic random motions
that contribute to DWI, which are essentially represented by molecular diffusion
and blood microcirculation (perfusion). Technological improvements have made
possible the routine use of DWI during abdominal MRI study. Several authors have
reported that the addition of DWI sequence can be of value for the evaluation of
patients with PDAC, especially improving the staging; nevertheless, it is still
unclear whether and how DWI could be helpful for identification,
characterization, prognostic stratification and follow-up during treatment. The
aim of this paper is to review up-to-date literature data regarding the
applications of DWI and IVIM to PDACs.