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Different Kinds of Paraneoplastic Syndromes in Childhood Neuroblastoma
#MMPMID26199695
Zhang YT
; Feng LH
; Zhang Z
; Zhong XD
; Chang J
Iran J Pediatr
2015[Feb]; 25
(1
): e266
PMID26199695
show ga
BACKGROUND: Clinical presentations of paraneoplastic syndromes in neuroblastoma
may multiply. Review of the clinical data and the literature on this syndrome may
help in the diagnosis of neuroblastoma. OBJECTIVES: In order to make more
accurate diagnosis, we reviewed the clinical data and the literature on this
syndrome. PATIENTS AND METHODS: Between April 2007 and April 2012, 68 children
were diagnosed with neuroblastoma or ganglioneuroblastoma in our institution, 9
of which presented exclusively with paraneoplastic syndromes and were not treated
with chemotherapy prior to diagnosis. After the diagnosis, all patients received
chemotherapy and operation on NB97 protocol. RESULTS: Among 68 pediatric patients
with neuroblastoma or ganglioneuroblastoma, 4 (5.9%) patients suffered from
neurological complications at diagnosis, 2 (2.9%) patients had digestive tract
disorders, 2 (2.9%) patients had immune diseases, and 1 (1.5%) suffered from
hematological disorder (without bone marrow involvement). All paraneoplastic
syndrome patients achieved complete remission on paraneoplastic syndrome before
completion of chemotherapy. CONCLUSIONS: Neuroblastoma may present with a range
of non-specific neurologic symptoms in addition to the well-known
opsoclonus-myoclonus syndrome and cerebellar ataxia. In any case, the presence of
unexplained neurologic manifestations and other common clinical presentations
such as rash, constipation, diarrhea, and especially immune disorders in an
otherwise healthy child had raised the possibility of paraneoplastic syndrome due
to the presence of an undiagnosed tumor.
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