Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1172/jci.insight.94920 http://scihub22266oqcxt.onion/10.1172/jci.insight.94920 C5841863!5841863 !28978809     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28978809 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28978809 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       JCI+Insight 2017 ; 2 (19 ): ä Nephropedia Template TP {{tp|p=28978809 |t=2017. Dietary potassium regulates vascular calcification and arterial stiffness |pdf=|usr=}}{{28978809 }} gab.com Text Dietary potassium regulates vascular calcification and arterial stiffness JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=28978809 #FOAvip Vascular calcification is a risk factor that predicts adverse cardiovascular complications of several diseases including atherosclerosis. Reduced dietary potassium intake has been linked to cardiovascular diseases such as hypertension and incidental stroke, although the underlying molecular mechanisms remain largely unknown. Using the ApoE-deficient mouse model, we demonstrated for the first time to our knowledge that reduced dietary potassium (0.3%) promoted atherosclerotic vascular calcification and increased aortic stiffness, compared with normal (0.7%) potassium-fed mice. In contrast, increased dietary potassium (2.1%) attenuated vascular calcification and aortic stiffness. Mechanistically, reduction in the potassium concentration to the lower limit of the physiological range increased intracellular calcium, which activated a cAMP response element-binding protein (CREB) signal that subsequently enhanced autophagy and promoted vascular smooth muscle cell (VSMC) calcification. Inhibition of calcium signals and knockdown of either CREB or ATG7, an autophagy regulator, attenuated VSMC calcification induced by low potassium. Consistently, elevated autophagy and CREB signaling were demonstrated in the calcified arteries from low potassium diet-fed mice as well as aortic arteries exposed to low potassium ex vivo. These studies established a potentially novel causative role of dietary potassium intake in regulating atherosclerotic vascular calcification and stiffness, and uncovered mechanisms that offer opportunities to develop therapeutic strategies to control vascular disease. Twit Text FOAVip Dietary potassium regulates vascular calcification and arterial stiffness ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=28978809 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28978809 #FOAvip English Wikipedia <ref>{{Cite pmid|28978809 }}</ref> Dietary potassium regulates vascular calcification and arterial stiffness #MMPMID28978809 Sun Y ; Byon CH ; Yang Y ; Bradley WE ; Dell'Italia LJ ; Sanders PW ; Agarwal A ; Wu H ; Chen Y JCI Insight 2017[Oct]; 2 (19 ): ä PMID28978809 show ga Vascular calcification is a risk factor that predicts adverse cardiovascular complications of several diseases including atherosclerosis. Reduced dietary potassium intake has been linked to cardiovascular diseases such as hypertension and incidental stroke, although the underlying molecular mechanisms remain largely unknown. Using the ApoE-deficient mouse model, we demonstrated for the first time to our knowledge that reduced dietary potassium (0.3%) promoted atherosclerotic vascular calcification and increased aortic stiffness, compared with normal (0.7%) potassium-fed mice. In contrast, increased dietary potassium (2.1%) attenuated vascular calcification and aortic stiffness. Mechanistically, reduction in the potassium concentration to the lower limit of the physiological range increased intracellular calcium, which activated a cAMP response element-binding protein (CREB) signal that subsequently enhanced autophagy and promoted vascular smooth muscle cell (VSMC) calcification. Inhibition of calcium signals and knockdown of either CREB or ATG7, an autophagy regulator, attenuated VSMC calcification induced by low potassium. Consistently, elevated autophagy and CREB signaling were demonstrated in the calcified arteries from low potassium diet-fed mice as well as aortic arteries exposed to low potassium ex vivo. These studies established a potentially novel causative role of dietary potassium intake in regulating atherosclerotic vascular calcification and stiffness, and uncovered mechanisms that offer opportunities to develop therapeutic strategies to control vascular disease. |Animals [MESH] |Aorta/drug effects/pathology/physiopathology [MESH] |Aortic Diseases/etiology/physiopathology/prevention & control [MESH] |Autophagy/drug effects [MESH] |Calcium/metabolism [MESH] |Cells, Cultured [MESH] |Cyclic AMP Response Element-Binding Protein/physiology [MESH] |Male [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout, ApoE [MESH] |Muscle, Smooth, Vascular/drug effects/pathology [MESH] |Potassium, Dietary/*administration & dosage/pharmacology [MESH] |Tissue Culture Techniques [MESH] |Vascular Calcification/*etiology/physiopathology/prevention & control [MESH]Dietary potassium regulates vascular calcification and arterial stiffn(epmc).pdf DeepDyve Pubget Overpricing