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2017 ; 37
(ä): 321-346
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Dietary Phosphorus Intake and the Kidney
#MMPMID28613982
Chang AR
; Anderson C
Annu Rev Nutr
2017[Aug]; 37
(ä): 321-346
PMID28613982
show ga
Although phosphorus is an essential nutrient required for multiple physiological
functions, recent research raises concerns that high phosphorus intake could have
detrimental effects on health. Phosphorus is abundant in the food supply of
developed countries, occurring naturally in protein-rich foods and as an additive
in processed foods. High phosphorus intake can cause vascular and renal
calcification, renal tubular injury, and premature death in multiple animal
models. Small studies in human suggest that high phosphorus intake may result in
positive phosphorus balance and correlate with renal calcification and
albuminuria. Although serum phosphorus is strongly associated with cardiovascular
disease, progression of kidney disease, and death, limited data exist linking
high phosphorus intake directly to adverse clinical outcomes. Further prospective
studies are needed to determine whether phosphorus intake is a modifiable risk
factor for kidney disease.