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10.1042/BST20160065 http://scihub22266oqcxt.onion/10.1042/BST20160065 C5682628!5682628 !27911726     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27911726 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biochem+Soc+Trans 2016 ; 44 (5 ): 1441-1454 Nephropedia Template TP {{tp|p=27911726 |t=2016. Dichotomous roles of TGF-? in human cancer |pdf=|usr=}}{{27911726 }} gab.com Text Dichotomous roles of TGF- in human cancer JO: Biochem Soc Trans http://www.kidney.de/pget.php?&tw=1&pmid=27911726 #FOAvip Transforming growth factor-? (TGF-?) mediates numerous biological processes, including embryonic development and the maintenance of cellular homeostasis in a context-dependent manner. Consistent with its central role in maintaining cellular homeostasis, inhibition of TGF-? signaling results in disruption of normal homeostatic processes and subsequent carcinogenesis, defining the TGF-? signaling pathway as a tumor suppressor. However, once carcinogenesis is initiated, the TGF-? signaling pathway promotes cancer progression. This dichotomous function of the TGF-? signaling pathway is mediated through altering effects on both the cancer cells, by inducing apoptosis and inhibiting proliferation, and the tumor microenvironment, by promoting angiogenesis and inhibiting immunosurveillance. Current studies support inhibition of TGF-? signaling either alone, or in conjunction with anti-angiogenic therapy or immunotherapy as a promising strategy for the treatment of human cancers. Twit Text FOAVip Dichotomous roles of TGF- in human cancer ????Biochem Soc Trans http://www.kidney.de/pget.php?&tw=1&pmid=27911726 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27911726 #FOAvip English Wikipedia <ref>{{Cite pmid|27911726 }}</ref> Dichotomous roles of TGF-? in human cancer #MMPMID27911726 Huang JJ ; Blobe GC Biochem Soc Trans 2016[Oct]; 44 (5 ): 1441-1454 PMID27911726 show ga Transforming growth factor-? (TGF-?) mediates numerous biological processes, including embryonic development and the maintenance of cellular homeostasis in a context-dependent manner. Consistent with its central role in maintaining cellular homeostasis, inhibition of TGF-? signaling results in disruption of normal homeostatic processes and subsequent carcinogenesis, defining the TGF-? signaling pathway as a tumor suppressor. However, once carcinogenesis is initiated, the TGF-? signaling pathway promotes cancer progression. This dichotomous function of the TGF-? signaling pathway is mediated through altering effects on both the cancer cells, by inducing apoptosis and inhibiting proliferation, and the tumor microenvironment, by promoting angiogenesis and inhibiting immunosurveillance. Current studies support inhibition of TGF-? signaling either alone, or in conjunction with anti-angiogenic therapy or immunotherapy as a promising strategy for the treatment of human cancers. |*Homeostasis [MESH] |*Signal Transduction [MESH] |Apoptosis [MESH] |Cell Proliferation [MESH] |Disease Progression [MESH] |Epithelial-Mesenchymal Transition [MESH] |Humans [MESH] |Models, Biological [MESH] |Neoplasms/*metabolism/pathology [MESH]Dichotomous roles of TGF-? in human cancer (epmc).pdf DeepDyve Pubget Overpricing