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2013 ; 89
(11
): 865-74
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Diagnosis and treatment of pulmonary hypertension in infancy
#MMPMID24083892
Steinhorn RH
Early Hum Dev
2013[Nov]; 89
(11
): 865-74
PMID24083892
show ga
Normal pulmonary vascular development in infancy requires maintenance of low
pulmonary vascular resistance after birth, and is necessary for normal lung
function and growth. The developing lung is subject to multiple genetic,
pathological and/or environmental influences that can adversely affect lung
adaptation, development, and growth, leading to pulmonary hypertension. New
classifications of pulmonary hypertension are beginning to account for these
diverse phenotypes, and or pulmonary hypertension in infants due to PPHN,
congenital diaphragmatic hernia, and bronchopulmonary dysplasia (BPD). The most
effective pharmacotherapeutic strategies for infants with PPHN are directed at
selective reduction of PVR, and take advantage of a rapidly advancing
understanding of the altered signaling pathways in the remodeled vasculature.
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