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2013 ; 60
(6
): 1489-511
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Diagnosis and management of autoimmune cytopenias in childhood
#MMPMID24237984
Teachey DT
; Lambert MP
Pediatr Clin North Am
2013[Dec]; 60
(6
): 1489-511
PMID24237984
show ga
The diagnosis and management of children with autoimmune cytopenias can be
challenging. Children can present with immune-mediated destruction of a
single-cell lineage or multiple cell lineages, including platelets (immune
thrombocytopenia [ITP]), erythrocytes (autoimmune hemolytic anemia), and
neutrophils (autoimmune neutropenia). Immune-mediated destruction can be primary
or secondary to a comorbid immunodeficiency, malignancy, rheumatologic condition,
or lymphoproliferative disorder. Treatment options generally consist of
nonspecific immune suppression or modulation. This nonspecific approach is
changing as recent insights into disease biology have led to targeted therapies,
including the use of thrombopoietin mimetics in ITP and sirolimus for cytopenias
associated with autoimmune lymphoproliferative syndrome.