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2015 ; 5
(11
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Diagnosis and Management of Latent Tuberculosis Infection
#MMPMID26054858
Muņoz L
; Stagg HR
; Abubakar I
Cold Spring Harb Perspect Med
2015[Jun]; 5
(11
): ä PMID26054858
show ga
The post-2015 World Health Organization global tuberculosis strategy recognizes
that elimination requires a focus on reducing the pool of latently infected
individuals, an estimated 30% of the global population, from which future
tuberculosis cases would be generated. Tackling latent tuberculosis infection
requires the identification and treatment of asymptomatic individuals to reduce
the risk of progression to active disease. Diagnosis of latent tuberculosis
infection is based on the detection of an immune response to Mycobacterium
tuberculosis antigens using either the tuberculin skin test or interferon-?
release assays. Current treatment requires the use of antibiotics for at least 3
months. In this article, we review the current knowledge of the natural history,
immunology, and pathogenesis of latent tuberculosis, describe key population
groups for screening and risk assessment, discuss clinical management in terms of
diagnosis and preventative treatment, and identify areas for future research.
|Antitubercular Agents/administration & dosage/adverse effects/*therapeutic use
[MESH]