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2015 ; 4
(7
): 1403-27
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Diabetic Nephropathy without Diabetes
#MMPMID26239683
López-Revuelta K
; Abreu AA
; Gerrero-Márquez C
; Stanescu RI
; Marín MI
; Fernández EP
J Clin Med
2015[Jul]; 4
(7
): 1403-27
PMID26239683
show ga
Diabetic nephropathy without diabetes (DNND), previously known as idiopathic
nodular glomerulosclerosis, is an uncommon entity and thus rarely suspected;
diagnosis is histological once diabetes is discarded. In this study we describe
two new cases of DNND and review the literature. We analyzed all the
individualized data of previous publications except one series of attached data.
DNND appears to be favored by recognized cardiovascular risk factors. However, in
contrast with diabetes, apparently no factor alone has been demonstrated to be
sufficient to develop DNND. Other factors not considered as genetic and
environmental factors could play a role or interact. The most plausible
hypothesis for the occurrence of DNND would be a special form of atherosclerotic
or metabolic glomerulopathy than can occur with or without diabetes. The clinical
spectrum of cardiovascular risk factors and histological findings support this
theory, with hypertension as one of the characteristic clinical features.