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2015 ; 2015
(ä): 697010
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Diabetic Kidney Disease: Pathophysiology and Therapeutic Targets
#MMPMID26064987
Toth-Manikowski S
; Atta MG
J Diabetes Res
2015[]; 2015
(ä): 697010
PMID26064987
show ga
Diabetes is a worldwide epidemic that has led to a rise in diabetic kidney
disease (DKD). Over the past two decades, there has been significant
clarification of the various pathways implicated in the pathogenesis of DKD.
Nonetheless, very little has changed in the way clinicians manage patients with
this disorder. Indeed, treatment is primarily centered on controlling
hyperglycemia and hypertension and inhibiting the renin-angiotensin system. The
purpose of this review is to describe the current understanding of how the
hemodynamic, metabolic, inflammatory, and alternative pathways are all entangled
in pathogenesis of DKD and detail the various therapeutic targets that may one
day play a role in quelling this epidemic.