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2015 ; 15
(4
): 381-93
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Developments in intracerebral stem cell grafts
#MMPMID25739415
Reyes S
; Tajiri N
; Borlongan CV
Expert Rev Neurother
2015[Apr]; 15
(4
): 381-93
PMID25739415
show ga
The field of stem cell therapy has emerged as a promising research area for brain
repair. Optimizing the safety and efficacy of the therapy for clinical trials
will require revisiting transplantation protocols. The cell delivery route stands
as a key translational item that warrants careful consideration in facilitating
the success of stem cell therapy in the clinic. Intracerebral administration,
compared to peripheral route, requires an invasive procedure to directly implant
stem cells into injured brain. Although invasive, intracerebral transplantation
circumvents the prohibitive blood brain barrier in allowing grafted cells when
delivered peripherally to penetrate the brain and reach the discreet damaged
brain tissues. This review will highlight milestone discoveries in cell therapy
for neurological disorders, with emphasis on intracerebral transplantation in
relevant animal models and provide insights necessary to optimize the safety and
efficacy of cell therapy for the treatment of Parkinson's disease, Huntington's
disease, stroke and traumatic brain injury.
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