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2017 ; 367
(3
): 677-685
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Developmental pathways in lung regeneration
#MMPMID27957616
Stabler CT
; Morrisey EE
Cell Tissue Res
2017[Mar]; 367
(3
): 677-685
PMID27957616
show ga
The key processes of lung development have been elucidated in the past several
decades, helping to identify and characterize the resident progenitor cells that
ultimately generate the mature organ. The adult lung is a complex organ
consisting in scores of different cell lineages that are remarkably quiescent in
the absence of injury. Despite low cellular turnover, the lung can respond
quickly and dramatically to acute damage, with spatially restricted stem and
progenitor cells re-entering the cell cycle and differentiating to promote
repair. The findings from lung developmental biology are now being used to
examine the mechanisms that underlie lung regeneration. The use of in vitro
models such as pluripotent stem cells and new methods of gene editing have
provided models for understanding lung disease and exploring the mechanisms of
lung regeneration and have raised the prospect of correcting lung dysfunction. We
outline the way that basic studies into lung developmental biology are now being
applied to lung regeneration, opening up new avenues of research that may
ultimately be harnessed for treatments of lung disease.
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