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10.1016/j.ecl.2015.02.001

http://scihub22266oqcxt.onion/10.1016/j.ecl.2015.02.001
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C4486052!4486052 !26038200
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suck abstract from ncbi


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pmid26038200
      Endocrinol+Metab+Clin+North+Am 2015 ; 44 (2 ): 243-74
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  • Development of adrenal cortex zonation #MMPMID26038200
  • Xing Y ; Lerario AM ; Rainey W ; Hammer GD
  • Endocrinol Metab Clin North Am 2015[Jun]; 44 (2 ): 243-74 PMID26038200 show ga
  • The human adult adrenal cortex is composed of the zona glomerulosa (zG), zona fasciculata (zF), and zona reticularis (zR), which are responsible for production of mineralocorticoids, glucocorticoids, and adrenal androgens, respectively. The final completion of cortical zonation in humans does not occur until puberty with the establishment of the zR and its production of adrenal androgens; a process called adrenarche. The maintenance of the adrenal cortex involves the centripetal displacement and differentiation of peripheral Sonic hedgehog-positive progenitors cells into zG cells that later transition to zF cells and subsequently zR cells.
  • |*Cell Differentiation [MESH]
  • |*Stem Cells/metabolism [MESH]
  • |Adrenal Cortex/*embryology/growth & development/metabolism [MESH]
  • |Androgens/metabolism [MESH]
  • |Glucocorticoids/metabolism [MESH]
  • |Hedgehog Proteins/metabolism [MESH]
  • |Humans [MESH]
  • |Mineralocorticoids/metabolism [MESH]
  • |Puberty/metabolism [MESH]
  • |Zona Fasciculata/embryology/growth & development/metabolism [MESH]
  • |Zona Glomerulosa/embryology/growth & development/metabolism [MESH]


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