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2017 ; 72
(7
): 897-903
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Development of a Rat Clinical Frailty Index
#MMPMID28158648
Yorke A
; Kane AE
; Hancock Friesen CL
; Howlett SE
; O'Blenes S
J Gerontol A Biol Sci Med Sci
2017[Jul]; 72
(7
): 897-903
PMID28158648
show ga
Rats are a commonly used model for aging studies, and a frailty assessment tool
for rats would be of considerable value. There has been a recent focus on the
development of preclinical models of frailty in mice. A mouse clinical frailty
index (FI) was developed based on clinical frailty assessment tools. This FI
measures the accumulation of clinically evident health-related deficits in mice.
This paper aimed to develop a rat clinical FI. Male Fischer 344 rats were aged
from 6 to 9 months (n = 12), and from 13 to 21 months (n = 41). A FI comprised of
27 health-related deficits was developed from a review of the literature and
consultation with a veterinarian. Deficits were scored 0 if absent, 0.5 if mild,
or 1 if severe. A FI score was determined for each rat every 3-4 months, and for
the older group mortality was assessed up to 21 months. Mean FI scores
significantly increased at each time point for the older rats. A high FI score
measured at both 17 months of age and terminally was also associated with
decreased probability of survival as assessed with Kaplan-Meier curves. The rat
clinical FI has significant value for use in aging and interventional studies.
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